macosx/TransmissionHelp/html/speed.html
If your router supports NAT-PMP, UPnP, or you have Apple AirPort, Transmission can do this automatically; just tick the checkbox in Preferences → Network.
eg. If your upload connection is 256 Kilobits/second, then you should cap it at 21 KB/s (( 256 / 8) * 0.66 = 21 ).
Remember, your download speed is proportional to how fast you upload. If there are many transfers running, then each transfer will only receive a small proportion of your upload bandwidth, reducing their respective download speeds. To avoid spreading your upload too thinly, a good rule of thumb is to have at least 128 Kb/s of upload bandwidth for every torrent you wish to run simultaneously.
eg. If your upload bandwidth is 256 Kb/s, then you should only have two ( 256 /128 = 2 ) downloading transfers in the queue.