website/content/ChapterFour/0400~0499/0433.Minimum-Genetic-Mutation.md
A gene string can be represented by an 8-character long string, with choices from "A", "C", "G", "T".
Suppose we need to investigate about a mutation (mutation from "start" to "end"), where ONE mutation is defined as ONE single character changed in the gene string.
For example, "AACCGGTT" -> "AACCGGTA" is 1 mutation.
Also, there is a given gene "bank", which records all the valid gene mutations. A gene must be in the bank to make it a valid gene string.
Now, given 3 things - start, end, bank, your task is to determine what is the minimum number of mutations needed to mutate from "start" to "end". If there is no such a mutation, return -1.
Note:
Example 1:
start: "AACCGGTT"
end: "AACCGGTA"
bank: ["AACCGGTA"]
return: 1
Example 2:
start: "AACCGGTT"
end: "AAACGGTA"
bank: ["AACCGGTA", "AACCGCTA", "AAACGGTA"]
return: 2
Example 3:
start: "AAAAACCC"
end: "AACCCCCC"
bank: ["AAAACCCC", "AAACCCCC", "AACCCCCC"]
return: 3
现在给定3个参数 — start, end, bank,分别代表起始基因序列,目标基因序列及基因库,请找出能够使起始基因序列变化为目标基因序列所需的最少变化次数。如果无法实现目标变化,请返回 -1。
注意:
package leetcode
// 解法一 BFS
func minMutation(start string, end string, bank []string) int {
wordMap, que, depth := getWordMap(bank, start), []string{start}, 0
for len(que) > 0 {
depth++
qlen := len(que)
for i := 0; i < qlen; i++ {
word := que[0]
que = que[1:]
candidates := getCandidates433(word)
for _, candidate := range candidates {
if _, ok := wordMap[candidate]; ok {
if candidate == end {
return depth
}
delete(wordMap, candidate)
que = append(que, candidate)
}
}
}
}
return -1
}
func getCandidates433(word string) []string {
var res []string
for i := 0; i < 26; i++ {
for j := 0; j < len(word); j++ {
if word[j] != byte(int('A')+i) {
res = append(res, word[:j]+string(int('A')+i)+word[j+1:])
}
}
}
return res
}
// 解法二 DFS
func minMutation1(start string, end string, bank []string) int {
endGene := convert(end)
startGene := convert(start)
m := make(map[uint32]struct{})
for _, gene := range bank {
m[convert(gene)] = struct{}{}
}
if _, ok := m[endGene]; !ok {
return -1
}
if check(startGene ^ endGene) {
return 1
}
delete(m, startGene)
step := make(map[uint32]int)
step[endGene] = 0
return dfsMutation(startGene, m, step)
}
func dfsMutation(start uint32, m map[uint32]struct{}, step map[uint32]int) int {
if v, ok := step[start]; ok {
return v
}
c := -1
step[start] = c
for k := range m {
if check(k ^ start) {
next := dfsMutation(k, m, step)
if next != -1 {
if c == -1 || c > next {
c = next + 1
}
}
}
}
step[start] = c
return c
}
func check(val uint32) bool {
if val == 0 {
return false
}
if val&(val-1) == 0 {
return true
}
for val > 0 {
if val == 3 {
return true
}
if val&3 != 0 {
return false
}
val >>= 2
}
return false
}
func convert(gene string) uint32 {
var v uint32
for _, c := range gene {
v <<= 2
switch c {
case 'C':
v |= 1
case 'G':
v |= 2
case 'T':
v |= 3
}
}
return v
}