public event CustomDrawColumnHeaderBackgroundEventHandler CustomDrawColumnHeaderBackground

Public Event CustomDrawColumnHeaderBackground As CustomDrawColumnHeaderBackgroundEventHandler

using System;
using System.Drawing;
using DevExpress.Spreadsheet;
using DevExpress.XtraSpreadsheet;
// ...
private void spreadsheetControl1_CustomDrawColumnHeaderBackground(object sender, 
    CustomDrawColumnHeaderBackgroundEventArgs e)
{
    // Cancel default painting for the column header background.
    e.Handled = true;

    // If the column header is under the mouse pointer or the column contains the active cell,
    // paint the column header background in Color 1.
    // Otherwise, use Color 2.
    if (e.ColumnIndex <= 4) {
        var backColor = e.IsHovered || (e.ColumnIndex == spreadsheetControl1.ActiveCell.ColumnIndex) ?
            //Color 1
            Color.FromArgb(200, 44, 74) :
            //Color 2
            Color.FromArgb(91, 155, 213);
        e.Cache.FillRectangle(e.Cache.GetSolidBrush(backColor), e.Bounds);
    }
}

Imports System
Imports System.Drawing
Imports DevExpress.Spreadsheet
Imports DevExpress.XtraSpreadsheet
' ...
Private Sub spreadsheetControl1_CustomDrawColumnHeaderBackground(ByVal sender As Object,
    ByVal e As CustomDrawColumnHeaderBackgroundEventArgs)
    ' Cancel default painting for the column header background.
    e.Handled = True

    ' If the column header is under the mouse pointer or the column contains the active cell,
    ' paint the column header background in Color 1.
    ' Otherwise, use Color 2.
    If e.ColumnIndex <= 4 Then
        Dim backColor = If(e.IsHovered OrElse (e.ColumnIndex = spreadsheetControl1.ActiveCell.ColumnIndex),
            Color.FromArgb(200, 44, 74), 'Color 1
            Color.FromArgb(91, 155, 213)) ' Color 2
        e.Cache.FillRectangle(e.Cache.GetSolidBrush(backColor), e.Bounds)
    End If
End Sub

AddHandler spreadsheetControl1.CustomDrawColumnHeader, AddressOf spreadsheetControl1_CustomDrawColumnHeader
AddHandler spreadsheetControl1.CustomDrawColumnHeaderBackground, AddressOf spreadsheetControl1_CustomDrawColumnHeaderBackground
AddHandler spreadsheetControl1.CustomDrawRowHeader, AddressOf spreadsheetControl1_CustomDrawRowHeader